| 5. Round | 05/09/2022 | Jong PSV | - | TOP Oss | 0:3 | ||||
| 7. Round | 16/09/2022 | VVV-Venlo | - | Jong PSV | 1:1 | ||||
| 9. Round | 30/09/2022 | ADO Den Haag | - | Jong PSV | 1:3 | ||||
| 10. Round | 07/10/2022 | Jong PSV | - | Telstar | 0:2 | ||||
| 11. Round | 14/10/2022 | MVV | - | Jong PSV | 1:1 | ||||
| 12. Round | 24/10/2022 | Jong PSV | - | Helmond Sport | 6:0 | ||||
| 13. Round | 28/10/2022 | FC Eindhoven | - | Jong PSV | 2:2 | ||||
| 14. Round | 07/11/2022 | Jong PSV | - | Almere City FC | 0:1 | ||||
| 15. Round | 11/11/2022 | De Graafschap | - | Jong PSV | 3:2 | ||||
| 16. Round | 17/11/2022 | Jong PSV | - | FC Utrecht (J) | 2:1 | ||||
| 17. Round | 12/12/2022 | AZ Alkmaar (J) | - | Jong PSV | 2:3 | ||||
| 26. Round | 27/02/2023 | Jong PSV | - | AZ Alkmaar (J) | 3:3 | ||||
| 28. Round | 10/03/2023 | Helmond Sport | - | Jong PSV | 3:0 | ||||
| 29. Round | 17/03/2023 | Jong PSV | - | De Graafschap | 2:1 | ||||
| 31. Round | 03/04/2023 | Jong PSV | - | Roda JC Kerkrade | 5:1 | ||||
| 35. Round | 28/04/2023 | Heracles Almelo | - | Jong PSV | 3:0 |
Netherlands