| 1. Round | 12/02/2022 | Banfield | - | San Lorenzo | 0:0 | ||||
| 2. Round | 17/02/2022 | Gimnasia de La Plata | - | San Lorenzo | 1:0 | ||||
| 3. Round | 22/02/2022 | San Lorenzo | - | Defensa y Justicia | 3:4 | ||||
| 4. Round | 28/02/2022 | Argentinos Juniors | - | San Lorenzo | 1:1 | ||||
| 5. Round | 05/03/2022 | San Lorenzo | - | River Plate | 0:1 |  |
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| 6. Round | 13/03/2022 | Talleres de Córdoba | - | San Lorenzo | 0:1 | ||||
| 7. Round | 19/03/2022 | San Lorenzo | - | Huracán | 0:0 | |
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| 8. Round | 03/04/2022 | San Lorenzo | - | Atlético Tucumán | 1:1 | ||||
| 9. Round | 09/04/2022 | Sarmiento de Junín | - | San Lorenzo | 2:1 | ||||
| 10. Round | 16/04/2022 | San Lorenzo | - | Platense | 2:2 | ||||
| 11. Round | 19/04/2022 | Unión de Santa Fe | - | San Lorenzo | 1:2 | ||||
| 12. Round | 23/04/2022 | San Lorenzo | - | Patronato de Paraná | 1:2 |  |
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