| 2. Round | 09/08/2005 | Doncaster Rovers | - | Milton Keynes Dons | 1:1 | ||||
| 3. Round | 13/08/2005 | Bradford City | - | Milton Keynes Dons | 2:0 | ||||
| 4. Round | 20/08/2005 | Milton Keynes Dons | - | Colchester United | 1:1 |  |
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| 5. Round | 27/08/2005 | Bristol City | - | Milton Keynes Dons | 2:2 | ||||
| 6. Round | 29/08/2005 | Milton Keynes Dons | - | Port Vale FC | 0:0 | ||||
| 8. Round | 10/09/2005 | Brentford FC | - | Milton Keynes Dons | 1:0 | ||||
| 7. Round | 13/09/2005 | Milton Keynes Dons | - | Swansea City | 1:3 | ||||
| 9. Round | 17/09/2005 | Milton Keynes Dons | - | Barnsley FC | 0:0 | ||||
| 10. Round | 24/09/2005 | Blackpool FC | - | Milton Keynes Dons | 3:2 | ||||
| 11. Round | 27/09/2005 | Milton Keynes Dons | - | Scunthorpe United | 1:0 | ||||
| 12. Round | 01/10/2005 | Milton Keynes Dons | - | Swindon Town | 3:1 | |
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| 13. Round | 08/10/2005 | Walsall FC | - | Milton Keynes Dons | 1:1 | ||||
| 14. Round | 15/10/2005 | Milton Keynes Dons | - | Chesterfield FC | 0:0 | ||||
| 16. Round | 29/10/2005 | Milton Keynes Dons | - | Rotherham United | 1:1 | ||||
| 23. Round | 26/12/2005 | Southend United | - | Milton Keynes Dons | 0:0 | ||||
| 28. Round | 14/01/2006 | Milton Keynes Dons | - | Yeovil Town | 1:1 |
England