| 1. Round | 03/04/2022 | Floriana FC | - | Gżira United | 0:1 | ||||
| 2. Round | 10/04/2022 | Gżira United | - | Birkirkara FC | 1:1 |  |
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| 3. Round | 24/04/2022 | Hamrun Spartans | - | Gżira United | 2:0 | ||||
| 4. Round | 01/05/2022 | Gżira United | - | Gudja United | 3:1 | ||||
| 5. Round | 07/05/2022 | Gżira United | - | Hibernians FC | 2:1 |
Malta