| 4. Round | 26/06/2022 | Orange County SC | - | Loudoun United | 3:1 |  |
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| 4. Round | 30/06/2022 | San Diego Loyal | - | Orange County SC | 2:1 | |
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| 5. Round | 03/07/2022 | Phoenix Rising | - | Orange County SC | 2:2 | |
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| 5. Round | 10/07/2022 | Orange County SC | - | Monterey Bay FC | 0:2 | ||||
| 5. Round | 17/07/2022 | Orange County SC | - | Miami FC | 0:0 | |
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| 5. Round | 24/07/2022 | Los Angeles Galaxy II | - | Orange County SC | 2:5 | |
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| 5. Round | 31/07/2022 | Orange County SC | - | San Diego Loyal | 2:3 | |
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| 6. Round | 13/08/2022 | Orange County SC | - | Phoenix Rising | 2:1 | |
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| 6. Round | 18/08/2022 | Orange County SC | - | Las Vegas Lights FC | 1:1 | |
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| 6. Round | 28/08/2022 | Tampa Bay Rowdies | - | Orange County SC | 3:1 | ||||
| 7. Round | 04/09/2022 | Orange County SC | - | Memphis 901 | 1:1 | |
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| 7. Round | 08/09/2022 | Monterey Bay FC | - | Orange County SC | 1:0 | ||||
| 7. Round | 11/09/2022 | Orange County SC | - | Los Angeles Galaxy II | 1:0 | |
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| 7. Round | 18/09/2022 | Sacramento Republic | - | Orange County SC | 4:0 | ||||
| 7. Round | 25/09/2022 | Pittsburgh Riverhounds | - | Orange County SC | 1:1 | |
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| 8. Round | 02/10/2022 | Orange County SC | - | San Diego Loyal | 2:2 | |
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USA
North Macedonia