| 1. Round | 18/01/2025 | UD Universitario | - | San Francisco FC | 1:1 | ||||
| 2. Round | 25/01/2025 | Independiente de La Chorrera | - | San Francisco FC | 1:0 |  |
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| 3. Round | 04/02/2025 | San Francisco FC | - | UMECIT | 0:2 | |
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| 4. Round | 09/02/2025 | Herrera FC | - | San Francisco FC | 0:1 | ||||
| 5. Round | 18/02/2025 | Veraguas United | - | San Francisco FC | 0:0 | |
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| 7. Round | 26/02/2025 | San Francisco FC | - | Plaza Amador | 0:1 | |
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| 8. Round | 11/03/2025 | Potros del Este | - | San Francisco FC | 0:1 | ||||
| 9. Round | 15/03/2025 | Sporting San Miguelito | - | San Francisco FC | 0:1 |  |
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| 10. Round | 23/03/2025 | Árabe Unido | - | San Francisco FC | 1:3 | ||||
| 11. Round | 29/03/2025 | San Francisco FC | - | Alianza | 1:2 | |
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Panama