| 1. Round | 11/08/2012 | AS Saint-Étienne | - | Lille OSC | 1:2 | ||||
| 2. Round | 17/08/2012 | Lille OSC | - | AS Nancy Lorraine | 1:1 | ||||
| 3. Round | 25/08/2012 | OGC Nice | - | Lille OSC | 2:2 | ||||
| 4. Round | 02/09/2012 | Lille OSC | - | Paris Saint-Germain | 1:2 | ||||
| 5. Round | 15/09/2012 | ESTAC Troyes | - | Lille OSC | 1:1 | ||||
| 6. Round | 23/09/2012 | Lille OSC | - | Olympique Lyonnais | 1:1 | ||||
| 7. Round | 28/09/2012 | Stade Rennais | - | Lille OSC | 2:0 | ||||
| 8. Round | 06/10/2012 | Lille OSC | - | AC Ajaccio | 2:0 | ||||
| 9. Round | 19/10/2012 | Girondins Bordeaux | - | Lille OSC | 1:1 | ||||
| 10. Round | 27/10/2012 | Lille OSC | - | Valenciennes FC | 2:1 | ||||
| 11. Round | 03/11/2012 | Évian Thonon Gaillard | - | Lille OSC | 0:2 | ||||
| 12. Round | 10/11/2012 | Lille OSC | - | Stade Brestois 29 | 1:0 |  |
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| 13. Round | 16/11/2012 | FC Lorient | - | Lille OSC | 2:0 | ||||
| 14. Round | 25/11/2012 | Olympique Marseille | - | Lille OSC | 1:0 | ||||
| 15. Round | 01/12/2012 | Lille OSC | - | SC Bastia | 0:0 |
France
