| Group B | 05/11/2009 | Genoa CFC | - | Lille OSC | 3:2 |  |
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| Group B | 02/12/2009 | Valencia CF | - | Lille OSC | 3:1 | ||||
| Group B | 17/12/2009 | Lille OSC | - | Slavia Praha | 3:1 | ||||
| 2. Round | 18/02/2010 | Lille OSC | - | Fenerbahçe | 2:1 | ||||
| 2. Round | 25/02/2010 | Fenerbahçe | - | Lille OSC | 1:1 | ||||
| Round of 16 | 11/03/2010 | Lille OSC | - | Liverpool FC | 1:0 | ||||
| Round of 16 | 18/03/2010 | Liverpool FC | - | Lille OSC | 3:0 |
France
