| 1. Round | 22/07/2018 | Club Tijuana | - | Deportivo Guadalajara | 2:1 |  |
|||
| 3. Round | 05/08/2018 | Deportivo Toluca | - | Deportivo Guadalajara | 2:2 | ||||
| 4. Round | 13/08/2018 | Deportivo Guadalajara | - | Santos Laguna | 1:2 | ||||
| 5. Round | 18/08/2018 | CD Veracruz | - | Deportivo Guadalajara | 0:2 | ||||
| 6. Round | 22/08/2018 | Deportivo Guadalajara | - | Club Necaxa | 1:0 | ||||
| 7. Round | 25/08/2018 | Atlas Guadalajara | - | Deportivo Guadalajara | 0:1 |  |
|||
| 8. Round | 02/09/2018 | Deportivo Guadalajara | - | CF Pachuca | 1:3 | ||||
| 12. Round | 07/10/2018 | Deportivo Guadalajara | - | Pumas UNAM | 1:2 | ||||
| 13. Round | 21/10/2018 | Lobos BUAP | - | Deportivo Guadalajara | 1:1 | ||||
| 17. Round | 25/11/2018 | Deportivo Guadalajara | - | UANL Tigres | 0:1 | |
Mexico