| 1. Round | 24/07/2011 | Pumas UNAM | - | Club San Luis | 2:0 |  |
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| 2. Round | 31/07/2011 | Club San Luis | - | Estudiantes Tecos | 2:1 |  |
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| 6. Round | 21/08/2011 | UANL Tigres | - | Club San Luis | 1:0 | ||||
| 7. Round | 28/08/2011 | Club San Luis | - | Deportivo Guadalajara | 2:0 | ||||
| 8. Round | 11/09/2011 | Atlas Guadalajara | - | Club San Luis | 1:1 | ||||
| 4. Round | 15/09/2011 | CF América | - | Club San Luis | 2:2 | ||||
| 9. Round | 18/09/2011 | Club San Luis | - | Santos Laguna | 0:1 | |
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| 10. Round | 25/09/2011 | CF Pachuca | - | Club San Luis | 1:1 | ||||
| 11. Round | 02/10/2011 | Club San Luis | - | Puebla FC | 2:1 | ||||
| 15. Round | 27/10/2011 | Club San Luis | - | Gallos Blancos (old) | 2:1 | |
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| 16. Round | 30/10/2011 | Club Tijuana | - | Club San Luis | 0:0 | |
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| 17. Round | 06/11/2011 | Club San Luis | - | Deportivo Toluca | 5:1 |
USA
Mexico