| 1. Round | 30/07/2009 | Club San Luis | - | CF América | 1:1 |  |
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| 3. Round | 09/08/2009 | Monarcas Morelia | - | Club San Luis | 2:1 | ||||
| 4. Round | 16/08/2009 | Club San Luis | - | CF Pachuca | 3:0 |  |
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| 5. Round | 23/08/2009 | Indios Juárez | - | Club San Luis | 1:1 | ||||
| 6. Round | 30/08/2009 | Club San Luis | - | Puebla FC | 0:0 | ||||
| 7. Round | 05/09/2009 | Atlas Guadalajara | - | Club San Luis | 0:0 | ||||
| 8. Round | 13/09/2009 | Club San Luis | - | Deportivo Guadalajara | 4:0 | |
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| 9. Round | 19/09/2009 | Cruz Azul | - | Club San Luis | 4:2 | ||||
| 10. Round | 27/09/2009 | Club San Luis | - | Jaguares Chiapas | 0:3 | |
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| 11. Round | 04/10/2009 | Deportivo Toluca | - | Club San Luis | 1:1 |  |
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| 14. Round | 31/10/2009 | Club San Luis | - | CF Monterrey | 0:3 | ||||
| 15. Round | 05/11/2009 | Estudiantes Tecos | - | Club San Luis | 1:1 |
USA
Mexico