| 4. Round | 30/07/2022 | Delfín SC | - | Guayaquil City | 1:3 | ||||
| 6. Round | 14/08/2022 | Técnico Universitario | - | Guayaquil City | 3:1 | ||||
| 7. Round | 23/08/2022 | Guayaquil City | - | Independiente del Valle | 0:1 | ||||
| 8. Round | 27/08/2022 | Aucas | - | Guayaquil City | 2:1 |  |
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| 9. Round | 03/09/2022 | Guayaquil City | - | 9 de Octubre | 1:1 | ||||
| 10. Round | 10/09/2022 | Cumbayá | - | Guayaquil City | 3:0 | ||||
| 11. Round | 20/09/2022 | Guayaquil City | - | Mushuc Runa | 4:1 | ||||
| 12. Round | 03/10/2022 | Barcelona | - | Guayaquil City | 1:1 | ||||
| 13. Round | 09/10/2022 | Guayaquil City | - | Gualaceo SC | 1:0 | ||||
| 14. Round | 16/10/2022 | LDU Quito | - | Guayaquil City | 2:0 | ||||
| 15. Round | 24/10/2022 | Guayaquil City | - | Orense SC | 1:1 |
Argentina
Ecuador