| 1. Round | 26/07/2021 | Barcelona | - | Manta | 2:0 | ||||
| 3. Round | 08/08/2021 | Barcelona | - | Guayaquil City | 2:1 |  |
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| 4. Round | 15/08/2021 | Orense SC | - | Barcelona | 1:0 | |
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| 6. Round | 30/08/2021 | Independiente del Valle | - | Barcelona | 1:0 | ||||
| 9. Round | 03/10/2021 | Barcelona | - | Mushuc Runa | 4:0 | ||||
| 11. Round | 25/10/2021 | Emelec | - | Barcelona | 2:1 | ||||
| 8. Round | 28/10/2021 | Aucas | - | Barcelona | 1:0 |
Argentina
Ecuador