| 1. Round | 05/08/2021 | Santos FC | - | Unión Huaral | 1:3 |  |
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| 6. Round | 01/09/2021 | Comerciantes Unidos | - | Santos FC | 2:1 | ||||
| 7. Round | 07/09/2021 | Santos FC | - | Atlético Grau | 0:0 | ||||
| 8. Round | 12/09/2021 | Santos FC | - | Unión Comercio | 0:1 | ||||
| 9. Round | 16/09/2021 | Llacuabamba | - | Santos FC | 0:2 | ||||
| 10. Round | 21/09/2021 | Santos FC | - | Los Chankas | 0:1 | ||||
| 11. Round | 30/09/2021 | Carlos Stein | - | Santos FC | 3:0 |
Argentina