| 5. Round | 06/02/2022 | Alianza | - | Luis Ángel Firpo | 0:0 | ||||
| 6. Round | 10/02/2022 | Santa Tecla FC | - | Alianza | 2:3 |  |
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| 7. Round | 13/02/2022 | Alianza | - | Platense Zacatecoluca | 1:0 | |
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| 8. Round | 20/02/2022 | Municipal Limeño | - | Alianza | 0:0 | |
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| 9. Round | 23/02/2022 | Once Municipal | - | Alianza | 1:2 | ||||
| 4. Round | 03/03/2022 | Alianza | - | FAS | 1:1 | |
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| 12. Round | 13/03/2022 | Isidro Metapán | - | Alianza | 0:0 | |
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| 13. Round | 20/03/2022 | Alianza | - | Jocoro FC | 2:1 | ||||
| 14. Round | 25/03/2022 | AD Chalatenango | - | Alianza | 2:0 | ||||
| 15. Round | 03/04/2022 | FAS | - | Alianza | 1:3 | ||||
| 16. Round | 10/04/2022 | Luis Ángel Firpo | - | Alianza | 0:1 | |
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| 17. Round | 13/04/2022 | Alianza | - | Santa Tecla FC | 2:2 |
El Salvador