| 4. Round | 11/08/2018 | Spartak Trnava | - | MFK Zemplín Michalovce | 3:0 |  |
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| 5. Round | 18/08/2018 | MFK Zemplín Michalovce | - | FK Senica | 1:1 | ||||
| 1. Round | 21/08/2018 | MFK Zemplín Michalovce | - | MŠK Žilina | 0:1 | ||||
| 6. Round | 25/08/2018 | Zlaté Moravce | - | MFK Zemplín Michalovce | 2:0 | ||||
| 7. Round | 01/09/2018 | MFK Zemplín Michalovce | - | FK Železiarne Podbrezová | 2:0 |  |
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| 8. Round | 15/09/2018 | ŠKF Sereď | - | MFK Zemplín Michalovce | 2:1 | ||||
| 10. Round | 29/09/2018 | MFK Zemplín Michalovce | - | MFK Ružomberok | 2:2 | ||||
| 11. Round | 06/10/2018 | AS Trenčín | - | MFK Zemplín Michalovce | 1:2 | ||||
| 12. Round | 20/10/2018 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:2 | |
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| 13. Round | 27/10/2018 | MFK Zemplín Michalovce | - | FC DAC 1904 | 2:1 | ||||
| 14. Round | 03/11/2018 | Slovan Bratislava | - | MFK Zemplín Michalovce | 6:0 | |
Slovakia