| 5. Round | 16/08/2010 | Zbrojovka Brno | - | FK Mladá Boleslav | 3:1 |  |
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| 7. Round | 30/08/2010 | Zbrojovka Brno | - | AC Sparta Praha | 0:5 | ||||
| 9. Round | 19/09/2010 | Zbrojovka Brno | - | Bohemians 1905 | 1:0 | ||||
| 10. Round | 25/09/2010 | Slovan Liberec | - | Zbrojovka Brno | 3:1 | ||||
| 11. Round | 03/10/2010 | Zbrojovka Brno | - | FC Hradec Králové | 1:2 | ||||
| 12. Round | 17/10/2010 | Viktoria Plzeň | - | Zbrojovka Brno | 4:1 | |
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| 13. Round | 24/10/2010 | Zbrojovka Brno | - | 1. FC Slovácko | 7:0 | ||||
| 15. Round | 07/11/2010 | Zbrojovka Brno | - | 1. FK Příbram | 0:1 | ||||
| 16. Round | 14/11/2010 | FK Ústí nad Labem | - | Zbrojovka Brno | 2:3 |
Czech Republic