| 1. Round | 05/08/2011 | Stuttgarter Kickers | - | Karlsruher SC II | 2:1 |  |
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| 3. Round | 19/08/2011 | Bayern München II | - | Karlsruher SC II | 2:5 | ||||
| 12. Round | 07/10/2011 | TSV 1860 München II | - | Karlsruher SC II | 1:1 | ||||
| 13. Round | 15/10/2011 | Karlsruher SC II | - | 1899 Hoffenheim II | 0:3 | ||||
| 14. Round | 22/10/2011 | Wormatia Worms | - | Karlsruher SC II | 2:2 | ||||
| 16. Round | 06/11/2011 | SC Pfullendorf | - | Karlsruher SC II | 1:0 | ||||
| 21. Round | 10/12/2011 | FC Memmingen | - | Karlsruher SC II | 1:1 | ||||
| 27. Round | 07/04/2012 | Karlsruher SC II | - | Eintracht Frankfurt II | 2:7 | ||||
| 29. Round | 14/04/2012 | Karlsruher SC II | - | TSV 1860 München II | 2:1 | ||||
| 30. Round | 22/04/2012 | 1899 Hoffenheim II | - | Karlsruher SC II | 2:3 | ||||
| 31. Round | 27/04/2012 | Karlsruher SC II | - | Wormatia Worms | 3:1 | ||||
| 32. Round | 04/05/2012 | Hessen Kassel | - | Karlsruher SC II | 1:2 | ||||
| 28. Round | 08/05/2012 | SpVgg Greuther Fürth II | - | Karlsruher SC II | 0:2 | ||||
| 33. Round | 12/05/2012 | Karlsruher SC II | - | SC Pfullendorf | 3:0 | ||||
| 34. Round | 18/05/2012 | FC Ingolstadt 04 II | - | Karlsruher SC II | 2:3 | |
Germany