| 1. Round | 16/01/2022 | Platense Zacatecoluca | - | Santa Tecla FC | 0:1 | ||||
| 2. Round | 23/01/2022 | Municipal Limeño | - | Platense Zacatecoluca | 2:1 | ||||
| 3. Round | 26/01/2022 | Platense Zacatecoluca | - | Atlético Marte | 1:1 | ||||
| 5. Round | 06/02/2022 | Platense Zacatecoluca | - | AD Chalatenango | 1:1 | ||||
| 6. Round | 10/02/2022 | Luis Ángel Firpo | - | Platense Zacatecoluca | 1:1 | ||||
| 7. Round | 13/02/2022 | Alianza | - | Platense Zacatecoluca | 1:0 | ||||
| 9. Round | 24/02/2022 | CD Águila | - | Platense Zacatecoluca | 2:2 | ||||
| 16. Round | 10/04/2022 | AD Chalatenango | - | Platense Zacatecoluca | 1:2 | ||||
| 17. Round | 13/04/2022 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:2 |  |
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| 18. Round | 17/04/2022 | Platense Zacatecoluca | - | Alianza | 0:1 | |
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| 19. Round | 24/04/2022 | Once Municipal | - | Platense Zacatecoluca | 1:2 | |
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| 20. Round | 27/04/2022 | Platense Zacatecoluca | - | CD Águila | 0:0 | |
El Salvador