| 6. Round | 20/09/2015 | Southampton FC | - | Manchester United | 2:3 | ||||
| 9. Round | 17/10/2015 | Everton FC | - | Manchester United | 0:3 |  |
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| 10. Round | 25/10/2015 | Manchester United | - | Manchester City | 0:0 | ||||
| 11. Round | 31/10/2015 | Crystal Palace | - | Manchester United | 0:0 | |
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| 12. Round | 07/11/2015 | Manchester United | - | West Bromwich Albion | 2:0 | |
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| 13. Round | 21/11/2015 | Watford FC | - | Manchester United | 1:2 | ||||
| 27. Round | 28/02/2016 | Manchester United | - | Arsenal FC | 3:2 | ||||
| 28. Round | 02/03/2016 | Manchester United | - | Watford FC | 1:0 | ||||
| 29. Round | 06/03/2016 | West Bromwich Albion | - | Manchester United | 1:0 | ||||
| 31. Round | 20/03/2016 | Manchester City | - | Manchester United | 0:1 | ||||
| 32. Round | 03/04/2016 | Manchester United | - | Everton FC | 1:0 | ||||
| 33. Round | 10/04/2016 | Tottenham Hotspur | - | Manchester United | 3:0 | ||||
| 34. Round | 16/04/2016 | Manchester United | - | Aston Villa | 1:0 | ||||
| 36. Round | 01/05/2016 | Manchester United | - | Leicester City | 1:1 | ||||
| 37. Round | 07/05/2016 | Norwich City | - | Manchester United | 0:1 | ||||
| 35. Round | 10/05/2016 | West Ham United | - | Manchester United | 3:2 |
Argentina
