| 3. Round | 22/09/1990 | Parma AC | - | SSC Napoli | 1:0 | ||||
| 4. Round | 29/09/1990 | SSC Napoli | - | Pisa SC | 2:1 | ||||
| 5. Round | 07/10/1990 | Genoa CFC | - | SSC Napoli | 1:1 | ||||
| 6. Round | 21/10/1990 | SSC Napoli | - | AC Milan | 1:1 |  |
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| 8. Round | 10/11/1990 | AS Bari | - | SSC Napoli | 0:0 | ||||
| 9. Round | 17/11/1990 | SSC Napoli | - | Sampdoria | 1:4 | ||||
| 10. Round | 24/11/1990 | Inter | - | SSC Napoli | 2:1 | ||||
| 13. Round | 15/12/1990 | SSC Napoli | - | Lazio Roma | 2:1 | ||||
| 14. Round | 29/12/1990 | AC Cesena | - | SSC Napoli | 0:0 | ||||
| 16. Round | 12/01/1991 | SSC Napoli | - | AS Roma | 1:1 | |
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| 18. Round | 26/01/1991 | SSC Napoli | - | US Lecce | 2:2 | ||||
| 19. Round | 02/02/1991 | Cagliari Calcio | - | SSC Napoli | 1:1 | ||||
| 24. Round | 09/03/1991 | ACF Fiorentina | - | SSC Napoli | 0:0 | ||||
| 25. Round | 16/03/1991 | SSC Napoli | - | AS Bari | 1:0 | |
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| 27. Round | 29/03/1991 | SSC Napoli | - | Inter | 1:1 | ||||
| 28. Round | 06/04/1991 | Torino FC | - | SSC Napoli | 1:1 | |
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| 29. Round | 13/04/1991 | SSC Napoli | - | Atalanta | 2:0 | ||||
| 30. Round | 20/04/1991 | Lazio Roma | - | SSC Napoli | 0:2 | ||||
| 31. Round | 04/05/1991 | SSC Napoli | - | AC Cesena | 1:0 | ||||
| 32. Round | 11/05/1991 | SSC Napoli | - | Juventus | 1:1 | ||||
| 33. Round | 18/05/1991 | AS Roma | - | SSC Napoli | 1:1 | |
Italy
