| 5. Round | 29/08/2021 | Dynamo Dresden | - | SC Paderborn 07 | 0:3 | ||||
| 10. Round | 15/10/2021 | SC Paderborn 07 | - | Jahn Regensburg | 1:1 | ||||
| 12. Round | 31/10/2021 | Karlsruher SC | - | SC Paderborn 07 | 2:4 | ||||
| 13. Round | 06/11/2021 | SC Paderborn 07 | - | FC Ingolstadt 04 | 2:1 | ||||
| 16. Round | 04/12/2021 | SV Sandhausen | - | SC Paderborn 07 | 1:1 | ||||
| 17. Round | 11/12/2021 | SC Paderborn 07 | - | SV Darmstadt 98 | 0:1 | ||||
| 19. Round | 15/01/2022 | 1. FC Nürnberg | - | SC Paderborn 07 | 1:2 | ||||
| 20. Round | 22/01/2022 | SC Paderborn 07 | - | Werder Bremen | 3:4 | ||||
| 21. Round | 05/02/2022 | FC St. Pauli | - | SC Paderborn 07 | 2:2 | ||||
| 24. Round | 25/02/2022 | SC Paderborn 07 | - | Erzgebirge Aue | 3:3 |  |
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| 26. Round | 12/03/2022 | SC Paderborn 07 | - | Fortuna Düsseldorf | 1:1 | ||||
| 27. Round | 20/03/2022 | Jahn Regensburg | - | SC Paderborn 07 | 1:0 | ||||
| 29. Round | 10/04/2022 | SC Paderborn 07 | - | Karlsruher SC | 2:2 | ||||
| 33. Round | 06/05/2022 | SC Paderborn 07 | - | SV Sandhausen | 2:0 | ||||
| 34. Round | 15/05/2022 | SV Darmstadt 98 | - | SC Paderborn 07 | 3:0 |
Germany
