| 1. Round | 23/07/2021 | FK Rostov [U20] | - | PFC Sochi [U20] | 3:1 | ||||
| 2. Round | 27/07/2021 | FK Krasnodar [U20] | - | FK Rostov [U20] | 1:2 |  |
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| 3. Round | 30/07/2021 | FK Rostov [U20] | - | Zenit St. Petersburg [U20] | 2:1 | |
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| 4. Round | 06/08/2021 | FK Khimki [U20] | - | FK Rostov [U20] | 0:2 | |
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| 5. Round | 13/08/2021 | Uor-5 Egorievsk [U20] | - | FK Rostov [U20] | 0:7 | |
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| 6. Round | 20/08/2021 | FK Rostov [U20] | - | Akhmat Grozny [U20] | 5:0 | ||||
| 7. Round | 27/08/2021 | FK Chertanovo [U20] | - | FK Rostov [U20] | 0:3 | |
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| 8. Round | 10/09/2021 | FK Rostov [U20] | - | Lokomotiv Moskva [U20] | 0:1 | ||||
| 11. Round | 01/10/2021 | PFC Sochi [U20] | - | FK Rostov [U20] | 1:3 | |
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| 12. Round | 15/10/2021 | FK Rostov [U20] | - | FK Krasnodar [U20] | 1:0 | |
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| 13. Round | 22/10/2021 | Akhmat Grozny [U20] | - | FK Rostov [U20] | 3:3 | |
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| 14. Round | 29/10/2021 | FK Rostov [U20] | - | Arsenal Tula [U20] | 4:0 | |
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| 15. Round | 06/11/2021 | Zenit St. Petersburg [U20] | - | FK Rostov [U20] | 2:1 | ||||
| 16. Round | 19/11/2021 | Lokomotiv Moskva [U20] | - | FK Rostov [U20] | 1:3 | |
Russia