| 1. Round | 23/08/2020 | FC Lorient | - | RC Strasbourg | 3:1 | ||||
| 2. Round | 29/08/2020 | RC Strasbourg | - | OGC Nice | 0:2 | ||||
| 3. Round | 12/09/2020 | AS Saint-Étienne | - | RC Strasbourg | 2:0 | ||||
| 4. Round | 20/09/2020 | RC Strasbourg | - | Dijon FCO | 1:0 | ||||
| 5. Round | 27/09/2020 | AS Monaco | - | RC Strasbourg | 3:2 | ||||
| 7. Round | 18/10/2020 | RC Strasbourg | - | Olympique Lyonnais | 2:3 | ||||
| 9. Round | 01/11/2020 | Stade de Reims | - | RC Strasbourg | 2:1 | ||||
| 10. Round | 06/11/2020 | RC Strasbourg | - | Olympique Marseille | 0:1 | ||||
| 15. Round | 16/12/2020 | Angers SCO | - | RC Strasbourg | 0:2 | ||||
| 16. Round | 20/12/2020 | RC Strasbourg | - | Girondins Bordeaux | 0:2 | ||||
| 18. Round | 06/01/2021 | RC Strasbourg | - | Nîmes Olympique | 5:0 |  |
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| 19. Round | 09/01/2021 | RC Lens | - | RC Strasbourg | 0:1 | ||||
| 20. Round | 17/01/2021 | RC Strasbourg | - | AS Saint-Étienne | 1:0 | ||||
| 24. Round | 06/02/2021 | Olympique Lyonnais | - | RC Strasbourg | 3:0 | ||||
| 29. Round | 14/03/2021 | Stade Rennais | - | RC Strasbourg | 1:0 |
Ghana
