| 3. Round | 08/08/2020 | CF Monterrey [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 4. Round | 13/08/2020 | CF América [U20] | - | Santos Laguna [U20] | 4:0 |  |
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| 5. Round | 16/08/2020 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 0:2 | ||||
| 6. Round | 21/08/2020 | Club Necaxa [U20] | - | Santos Laguna [U20] | 1:2 | ||||
| 7. Round | 30/08/2020 | Santos Laguna [U20] | - | Gallos Blancos [U20] | 3:1 | |
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| 8. Round | 04/09/2020 | FC Juárez [U20] | - | Santos Laguna [U20] | 0:1 | |
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| 10. Round | 12/09/2020 | UANL Tigres [U20] | - | Santos Laguna [U20] | 2:0 | ||||
| 11. Round | 20/09/2020 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 1:0 | |
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| 12. Round | 27/09/2020 | Santos Laguna [U20] | - | Club Tijuana [U20] | 5:1 | ||||
| 13. Round | 02/10/2020 | Puebla FC [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 1. Round | 10/10/2020 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 2. Round | 13/11/2020 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 2:2 | |
Mexico