| 8. Round | 28/02/2021 | Real Santander | - | Deportes Quindío | 1:1 | ||||
| 9. Round | 04/03/2021 | Bogotá FC | - | Deportes Quindío | 1:1 | ||||
| 10. Round | 07/03/2021 | Deportes Quindío | - | Fortaleza FC | 2:1 | ||||
| 11. Round | 14/03/2021 | Leones FC | - | Deportes Quindío | 0:2 | ||||
| 12. Round | 22/03/2021 | Deportes Quindío | - | Atlético Huila | 0:0 | ||||
| 13. Round | 26/03/2021 | Cortuluá | - | Deportes Quindío | 0:0 | ||||
| 14. Round | 03/04/2021 | Deportes Quindío | - | Atlético FC | 1:0 |
Colombia