| 2. Round | 21/08/2021 | sc Heerenveen | - | RKC Waalwijk | 3:2 | ||||
| 3. Round | 29/08/2021 | sc Heerenveen | - | AZ Alkmaar | 1:3 | ||||
| 4. Round | 12/09/2021 | FC Groningen | - | sc Heerenveen | 1:1 |  |
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| 5. Round | 18/09/2021 | sc Heerenveen | - | Fortuna Sittard | 1:0 | ||||
| 6. Round | 22/09/2021 | Feyenoord | - | sc Heerenveen | 3:1 | ||||
| 7. Round | 26/09/2021 | sc Heerenveen | - | FC Twente | 2:3 | ||||
| 8. Round | 02/10/2021 | PEC Zwolle | - | sc Heerenveen | 0:1 | ||||
| 13. Round | 21/11/2021 | sc Heerenveen | - | Willem II | 2:1 | ||||
| 20. Round | 22/01/2022 | sc Heerenveen | - | PEC Zwolle | 0:1 | ||||
| 21. Round | 05/02/2022 | Fortuna Sittard | - | sc Heerenveen | 2:0 | ||||
| 22. Round | 13/02/2022 | sc Heerenveen | - | NEC Nijmegen | 0:1 | ||||
| 23. Round | 20/02/2022 | PSV Eindhoven | - | sc Heerenveen | 3:1 | ||||
| 24. Round | 27/02/2022 | sc Heerenveen | - | FC Utrecht | 1:2 | ||||
| 25. Round | 05/03/2022 | Willem II | - | sc Heerenveen | 0:0 | ||||
| 30. Round | 23/04/2022 | AZ Alkmaar | - | sc Heerenveen | 2:1 | ||||
| 31. Round | 01/05/2022 | sc Heerenveen | - | SC Cambuur | 3:3 | |
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| 32. Round | 08/05/2022 | Vitesse | - | sc Heerenveen | 1:2 | ||||
| 33. Round | 11/05/2022 | AFC Ajax | - | sc Heerenveen | 5:0 | ||||
| 34. Round | 15/05/2022 | sc Heerenveen | - | Go Ahead Eagles | 3:1 | |
Netherlands