| Group K | 15/09/2011 | Fulham FC | - | FC Twente | 1:1 | ||||
| Group K | 29/09/2011 | FC Twente | - | Wisła Kraków | 4:1 | ||||
| Group K | 20/10/2011 | Odense BK | - | FC Twente | 1:4 | ||||
| Group K | 03/11/2011 | FC Twente | - | Odense BK | 3:2 |  |
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| Group K | 01/12/2011 | FC Twente | - | Fulham FC | 1:0 | ||||
| 2. Round | 16/02/2012 | FC Steaua Bucureşti | - | FC Twente | 0:1 | ||||
| 2. Round | 23/02/2012 | FC Twente | - | FC Steaua Bucureşti | 1:0 |  |
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| Round of 16 | 08/03/2012 | FC Twente | - | FC Schalke 04 | 1:0 | ||||
| Round of 16 | 15/03/2012 | FC Schalke 04 | - | FC Twente | 4:1 |
Netherlands
Curaçao 
