| 1. Round | 11/09/2021 | SV Lippstadt 08 [Youth B] | - | SG Unterrath 12/24 [Youth B] | 0:2 |  |
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| 2. Round | 18/09/2021 | Bor. Mönchengladbach [Youth B] | - | SV Lippstadt 08 [Youth B] | 3:0 | ||||
| 3. Round | 26/09/2021 | SV Lippstadt 08 [Youth B] | - | Borussia Dortmund [Youth B] | 0:2 | ||||
| 6. Round | 30/10/2021 | Bayer Leverkusen [Youth B] | - | SV Lippstadt 08 [Youth B] | 2:0 | ||||
| 10. Round | 11/12/2021 | SV Lippstadt 08 [Youth B] | - | Alemannia Aachen [Youth B] | 1:4 | ||||
| 9. Round | 13/02/2022 | Preußen Münster [Youth B] | - | SV Lippstadt 08 [Youth B] | 3:0 | ||||
| 11. Round | 20/02/2022 | Fortuna Köln [Youth B] | - | SV Lippstadt 08 [Youth B] | 3:1 |  |
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| 14. Round | 13/03/2022 | SV Lippstadt 08 [Youth B] | - | SC Paderborn 07 [Youth B] | 0:1 | ||||
| 12. Round | 30/03/2022 | SV Lippstadt 08 [Youth B] | - | FC Hennef 05 [Youth B] | 3:0 | |
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| 15. Round | 02/04/2022 | Rot-Weiss Essen [Youth B] | - | SV Lippstadt 08 [Youth B] | 0:3 | ||||
| 16. Round | 09/04/2022 | 1. FC Köln [Youth B] | - | SV Lippstadt 08 [Youth B] | 5:1 | |
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| 17. Round | 23/04/2022 | Wuppertaler SV [Youth B] | - | SV Lippstadt 08 [Youth B] | 0:2 |
Germany