| 1. Round | 24/07/2021 | FK Khimki | - | Zenit St. Petersburg | 1:3 | ||||
| 2. Round | 01/08/2021 | FK Rostov | - | Zenit St. Petersburg | 2:4 | ||||
| 6. Round | 26/08/2021 | Zenit St. Petersburg | - | CSKA Moskva | 1:0 | ||||
| 7. Round | 11/09/2021 | Zenit St. Petersburg | - | Akhmat Grozny | 3:1 | ||||
| 8. Round | 20/09/2021 | Rubin Kazan | - | Zenit St. Petersburg | 1:3 | ||||
| 9. Round | 25/09/2021 | Zenit St. Petersburg | - | Krylia Sovetov | 2:1 | ||||
| 10. Round | 03/10/2021 | Zenit St. Petersburg | - | FK Sochi | 1:2 | ||||
| 12. Round | 24/10/2021 | Zenit St. Petersburg | - | Spartak Moskva | 7:1 | ||||
| 13. Round | 29/10/2021 | Zenit St. Petersburg | - | Dinamo Moskva | 4:1 |
Russia