| 1. Round | 26/03/2022 | El Nacional [Women] | - | Guayaquil City [Women] | 2:0 | ||||
| 2. Round | 01/04/2022 | Universidad Católica [Women] | - | Guayaquil City [Women] | 5:0 |  |
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| 3. Round | 15/04/2022 | Guayaquil City [Women] | - | LDU Quito [Women] | 1:4 |  |
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| 4. Round | 23/04/2022 | Técnico Universitario [Women] | - | Guayaquil City [Women] | 0:1 | |
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| 5. Round | 29/04/2022 | Guayaquil City [Women] | - | Barcelona [Women] | 0:2 | |
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| 6. Round | 09/05/2022 | UPS Carneras [Women] | - | Guayaquil City [Women] | 3:1 | |
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| 8. Round | 22/05/2022 | Guayaquil City [Women] | - | El Nacional [Women] | 1:2 | ||||
| 9. Round | 28/05/2022 | Guayaquil City [Women] | - | Universidad Católica [Women] | 1:3 | |
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| 10. Round | 03/06/2022 | LDU Quito [Women] | - | Guayaquil City [Women] | 8:0 | ||||
| 11. Round | 11/06/2022 | Guayaquil City [Women] | - | Técnico Universitario [Women] | 1:2 |
Ecuador