1. Round | 13/08/2021 | Gudja United | - | Sirens FC | 0:1 | ||||
2. Round | 20/08/2021 | Sirens FC | - | Mosta FC | 1:1 | ||||
3. Round | 12/09/2021 | Sirens FC | - | Hibernians FC | 1:3 | ||||
4. Round | 18/09/2021 | St. Luċija FC | - | Sirens FC | 1:3 | ||||
5. Round | 26/09/2021 | Sirens FC | - | Sliema Wanderers | 2:2 | ||||
6. Round | 17/10/2021 | Valletta FC | - | Sirens FC | 3:1 | ||||
7. Round | 24/10/2021 | Sirens FC | - | Birkirkara FC | 3:2 | ||||
9. Round | 21/11/2021 | Sirens FC | - | Balzan FC | 1:6 | ||||
10. Round | 27/11/2021 | Floriana FC | - | Sirens FC | 1:2 | ||||
11. Round | 04/12/2021 | Sirens FC | - | Gżira United | 1:3 | ||||
12. Round | 13/12/2021 | Sirens FC | - | Gudja United | 0:0 | ||||
13. Round | 18/12/2021 | Mosta FC | - | Sirens FC | 2:3 | ||||
14. Round | 18/01/2022 | Hibernians FC | - | Sirens FC | 1:1 | ||||
15. Round | 23/01/2022 | Sirens FC | - | St. Luċija FC | 2:1 | ||||
16. Round | 29/01/2022 | Sliema Wanderers | - | Sirens FC | 1:0 |