| 1. Round | 18/09/2021 | Club Tijuana [] | - | Pumas UNAM [] | 1:2 | ||||
| 2. Round | 25/09/2021 | Pumas UNAM [] | - | FC Juárez [] | 5:0 |  |
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| 4. Round | 09/10/2021 | Pumas UNAM [] | - | CF Pachuca [] | 1:1 | ||||
| 3. Round | 20/10/2021 | CF América [] | - | Pumas UNAM [] | 3:2 | ||||
| 6. Round | 23/10/2021 | Gallos Blancos [] | - | Pumas UNAM [] | 2:2 | ||||
| 7. Round | 30/10/2021 | Pumas UNAM [] | - | Cruz Azul [] | 2:2 | ||||
| 8. Round | 06/11/2021 | Deportivo Toluca [] | - | Pumas UNAM [] | 3:1 | ||||
| 9. Round | 13/11/2021 | Pumas UNAM [] | - | Club Tijuana [] | 2:1 | ||||
| 10. Round | 20/11/2021 | Puebla FC [] | - | Pumas UNAM [] | 2:4 | |
Mexico