| 10. Round | 02/10/2021 | Exeter City | - | Walsall FC | 2:2 | ||||
| 11. Round | 09/10/2021 | Stevenage FC | - | Exeter City | 2:2 | ||||
| 17. Round | 20/11/2021 | Exeter City | - | Carlisle United | 2:1 | ||||
| 18. Round | 23/11/2021 | Colchester United | - | Exeter City | 3:1 | ||||
| 20. Round | 07/12/2021 | Exeter City | - | Northampton Town | 1:2 | ||||
| 21. Round | 11/12/2021 | Exeter City | - | Tranmere Rovers | 0:1 | ||||
| 30. Round | 05/02/2022 | Swindon Town | - | Exeter City | 1:2 | ||||
| 26. Round | 15/02/2022 | Exeter City | - | Harrogate Town | 4:3 | ||||
| 34. Round | 26/02/2022 | Bristol Rovers | - | Exeter City | 1:1 | ||||
| 35. Round | 04/03/2022 | Mansfield Town | - | Exeter City | 2:1 | ||||
| 23. Round | 08/03/2022 | Exeter City | - | Swindon Town | 3:1 | ||||
| 36. Round | 12/03/2022 | Exeter City | - | Salford City | 0:0 | ||||
| 37. Round | 15/03/2022 | Exeter City | - | Crawley Town | 2:1 | ||||
| 39. Round | 26/03/2022 | Exeter City | - | Stevenage FC | 2:1 | ||||
| 40. Round | 02/04/2022 | Newport County | - | Exeter City | 0:1 | ||||
| 41. Round | 09/04/2022 | Carlisle United | - | Exeter City | 0:1 | ||||
| 43. Round | 18/04/2022 | Tranmere Rovers | - | Exeter City | 2:0 | ||||
| 45. Round | 30/04/2022 | Northampton Town | - | Exeter City | 1:1 |
England