| 1. Round | 24/02/2022 | Academia Puerto Cabello | - | Portuguesa FC | 1:1 | ||||
| 8. Round | 15/04/2022 | Academia Puerto Cabello | - | Monagas | 0:2 | ||||
| 11. Round | 08/05/2022 | Universidad Central | - | Academia Puerto Cabello | 2:2 | ||||
| 12. Round | 15/05/2022 | Academia Puerto Cabello | - | Carabobo FC | 1:1 | ||||
| 13. Round | 20/05/2022 | Zamora FC | - | Academia Puerto Cabello | 1:0 | ||||
| 14. Round | 29/05/2022 | Academia Puerto Cabello | - | Metropolitanos FC | 0:2 | ||||
| 15. Round | 04/06/2022 | Zulia FC | - | Academia Puerto Cabello | 4:1 | ||||
| 16. Round | 11/06/2022 | Academia Puerto Cabello | - | Zulia FC | 2:2 |  |
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| 17. Round | 19/06/2022 | Metropolitanos FC | - | Academia Puerto Cabello | 0:2 | |
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| 18. Round | 04/07/2022 | Academia Puerto Cabello | - | Zamora FC | 0:0 | ||||
| 19. Round | 09/07/2022 | Carabobo FC | - | Academia Puerto Cabello | 0:1 | |
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| 22. Round | 31/07/2022 | Academia Puerto Cabello | - | Deportivo Lara | 3:2 | ||||
| 26. Round | 27/08/2022 | Academia Puerto Cabello | - | Hermanos Colmenarez | 1:2 | ||||
| 27. Round | 03/09/2022 | Academia Puerto Cabello | - | Deportivo Táchira | 1:2 | ||||
| 28. Round | 09/09/2022 | Aragua FC | - | Academia Puerto Cabello | 0:1 |
Venezuela