| 1. Round | 12/08/2000 | KV Mechelen | - | KRC Genk | 0:0 | ||||
| 2. Round | 19/08/2000 | KAA Gent | - | KV Mechelen | 2:1 | ||||
| 3. Round | 26/08/2000 | KV Mechelen | - | Excelsior Mouscron | 1:5 | ||||
| 5. Round | 09/09/2000 | KV Mechelen | - | Standard Liège | 0:4 | ||||
| 6. Round | 16/09/2000 | RAA La Louviére | - | KV Mechelen | 2:2 | ||||
| 7. Round | 23/09/2000 | KV Mechelen | - | Germinal Beerschot | 2:3 | ||||
| 8. Round | 01/10/2000 | Club Brugge KV | - | KV Mechelen | 5:2 | ||||
| 9. Round | 15/10/2000 | KRC Harelbeke | - | KV Mechelen | 1:0 | ||||
| 11. Round | 28/10/2000 | Sint-Truidense VV | - | KV Mechelen | 1:0 | ||||
| 14. Round | 25/11/2000 | KV Mechelen | - | RSC Charleroi | 4:3 | ||||
| 16. Round | 09/12/2000 | KV Mechelen | - | RSC Anderlecht | 0:2 | ||||
| 17. Round | 16/12/2000 | Lierse SK | - | KV Mechelen | 1:1 | ||||
| 18. Round | 20/12/2000 | KRC Genk | - | KV Mechelen | 3:1 |  |
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| 19. Round | 20/01/2001 | KV Mechelen | - | KAA Gent | 3:3 | ||||
| 20. Round | 28/01/2001 | Excelsior Mouscron | - | KV Mechelen | 4:2 | ||||
| 21. Round | 03/02/2001 | KV Mechelen | - | Sporting Lokeren | 0:3 | ||||
| 23. Round | 17/02/2001 | KV Mechelen | - | RAA La Louviére | 0:0 |
Peru