| 1. Round | 22/01/2019 | San Lorenzo | - | River Plate | 1:0 | ||||
| 2. Round | 28/01/2019 | River Plate | - | Sportivo Luqueño | 2:1 | ||||
| 4. Round | 05/02/2019 | River Plate | - | Sol de América | 1:0 | ||||
| 5. Round | 10/02/2019 | Cerro Porteño | - | River Plate | 3:1 | ||||
| 9. Round | 04/03/2019 | Guaraní | - | River Plate | 2:1 | ||||
| 11. Round | 16/03/2019 | River Plate | - | Club Nacional | 1:1 | ||||
| 12. Round | 23/03/2019 | River Plate | - | San Lorenzo | 2:1 |  |
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| 13. Round | 01/04/2019 | Sportivo Luqueño | - | River Plate | 3:1 |  |
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| 16. Round | 14/04/2019 | River Plate | - | Cerro Porteño | 1:5 | ||||
| 17. Round | 21/04/2019 | Libertad | - | River Plate | 2:1 | ||||
| 18. Round | 28/04/2019 | River Plate | - | Deportivo Capiatá | 1:0 | ||||
| 19. Round | 01/05/2019 | General Díaz | - | River Plate | 0:1 | ||||
| 20. Round | 07/05/2019 | River Plate | - | Guaraní | 0:1 | ||||
| 21. Round | 14/05/2019 | River Plate | - | Club Olimpia | 2:2 | ||||
| 22. Round | 19/05/2019 | Club Nacional | - | River Plate | 0:0 | |
Paraguay