| 1. Round | 19/01/2025 | Matagalpa FC | - | Diriangén FC | 0:4 | ||||
| 3. Round | 26/01/2025 | Real Estelí FC | - | Matagalpa FC | 2:0 |  |
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| 5. Round | 02/02/2025 | H&H Export Sébaco | - | Matagalpa FC | 1:1 | |
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| 6. Round | 09/02/2025 | Matagalpa FC | - | CD Walter Ferretti | 0:1 | |
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| 2. Round | 13/02/2025 | Club Deportivo Ocotal | - | Matagalpa FC | 0:1 | |
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| 8. Round | 19/02/2025 | Matagalpa FC | - | UNAN Managua | 2:2 |  |
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| 9. Round | 22/02/2025 | Matagalpa FC | - | ART Municipal Jalapa | 3:3 | |
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| 4. Round | 26/02/2025 | Matagalpa FC | - | Rancho Santana | 2:1 | |
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| 10. Round | 03/03/2025 | Diriangén FC | - | Matagalpa FC | 3:1 |  |
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| 11. Round | 08/03/2025 | Matagalpa FC | - | Club Deportivo Ocotal | 3:0 | |
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| 12. Round | 12/03/2025 | Matagalpa FC | - | Real Estelí FC | 2:4 | |
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| 13. Round | 23/03/2025 | Rancho Santana | - | Matagalpa FC | 1:1 | |
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| 15. Round | 08/04/2025 | CD Walter Ferretti | - | Matagalpa FC | 0:0 | |
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| 16. Round | 13/04/2025 | Matagalpa FC | - | Managua FC | 3:1 | |
Nicaragua