| 1. Round | 20/08/2022 | Mosta FC | - | Gudja United | 1:2 | ||||
| 4. Round | 10/09/2022 | Pietá Hotspurs | - | Mosta FC | 1:4 | ||||
| 5. Round | 01/10/2022 | Mosta FC | - | Sirens FC | 1:1 | ||||
| 6. Round | 08/10/2022 | Floriana FC | - | Mosta FC | 1:1 | ||||
| 7. Round | 15/10/2022 | Mosta FC | - | Valletta FC | 3:1 | ||||
| 8. Round | 22/10/2022 | Hamrun Spartans | - | Mosta FC | 2:1 | ||||
| 10. Round | 04/11/2022 | Mosta FC | - | Gżira United | 0:2 | ||||
| 11. Round | 13/11/2022 | Balzan FC | - | Mosta FC | 1:2 | ||||
| 12. Round | 04/12/2022 | Mosta FC | - | Żebbuġ Rangers | 2:0 | ||||
| 14. Round | 16/12/2022 | Gudja United | - | Mosta FC | 2:1 |
Nigeria