| 12. Round | 29/10/1921 | Bolton Wanderers | - | Birmingham FC | 1:2 |  |
|||
| 13. Round | 05/11/1921 | Birmingham FC | - | Arsenal FC | 0:1 | ||||
| 14. Round | 12/11/1921 | Arsenal FC | - | Birmingham FC | 5:2 | |
|||
| 15. Round | 19/11/1921 | Blackburn Rovers | - | Birmingham FC | 1:1 | |
|||
| 27. Round | 04/02/1922 | Birmingham FC | - | Liverpool FC | 0:2 | ||||
| 26. Round | 08/02/1922 | Newcastle United | - | Birmingham FC | 0:1 | ||||
| 28. Round | 11/02/1922 | Liverpool FC | - | Birmingham FC | 1:0 | ||||
| 29. Round | 18/02/1922 | Birmingham FC | - | Manchester United | 0:1 | ||||
| 30. Round | 25/02/1922 | Manchester United | - | Birmingham FC | 1:1 | |
|||
| 32. Round | 11/03/1922 | Aston Villa | - | Birmingham FC | 1:1 | ||||
| 31. Round | 15/03/1922 | Birmingham FC | - | Aston Villa | 1:0 | ||||
| 33. Round | 18/03/1922 | Middlesbrough FC | - | Birmingham FC | 1:1 | ||||
| 34. Round | 25/03/1922 | Birmingham FC | - | Middlesbrough FC | 4:3 | |
|||
| 35. Round | 01/04/1922 | Birmingham FC | - | Tottenham Hotspur | 0:3 | ||||
| 36. Round | 08/04/1922 | Tottenham Hotspur | - | Birmingham FC | 2:1 | ||||
| 38. Round | 15/04/1922 | Bradford City | - | Birmingham FC | 1:2 | |
|||
| 39. Round | 18/04/1922 | Birmingham FC | - | Manchester City | 3:1 | |
England