| 1. Round | 20/05/2021 | Unión Huaral | - | Santos FC | 1:3 |  |
 |
||
| 2. Round | 26/05/2021 | Santos FC | - | Chavelines Juniors | 2:1 | ||||
| 3. Round | 30/05/2021 | Deportivo Coopsol | - | Santos FC | 1:0 | ||||
| 4. Round | 04/06/2021 | Santos FC | - | Juan Aurich | 0:0 | ||||
| 5. Round | 26/06/2021 | Pirata | - | Santos FC | 2:2 | ||||
| 6. Round | 03/07/2021 | Santos FC | - | Comerciantes Unidos | 4:2 | ||||
| 7. Round | 08/07/2021 | Atlético Grau | - | Santos FC | 4:1 | ||||
| 9. Round | 16/07/2021 | Santos FC | - | Llacuabamba | 0:1 | |
|||
| 10. Round | 22/07/2021 | Cultural Santa Rosa | - | Santos FC | 3:0 | |
Colombia