| 1. Round | 08/07/2021 | MŠK Žilina | - | Dila Gori | 5:1 | ||||
| 1. Round | 15/07/2021 | Dila Gori | - | MŠK Žilina | 2:1 | ||||
| 2. Round | 22/07/2021 | Apollon Limassol | - | MŠK Žilina | 1:3 |  |
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| 2. Round | 29/07/2021 | MŠK Žilina | - | Apollon Limassol | 2:2 | ||||
| 3. Round | 05/08/2021 | Tobyl Kostanay | - | MŠK Žilina | 0:1 | ||||
| 3. Round | 12/08/2021 | MŠK Žilina | - | Tobyl Kostanay | 5:0 | ||||
| Play-offs | 19/08/2021 | FK Jablonec | - | MŠK Žilina | 5:1 | ||||
| Play-offs | 26/08/2021 | MŠK Žilina | - | FK Jablonec | 0:3 |
Poland