| 1. Round | 22/08/2021 | Olympique Lyonnais [Youth] | - | AS Nancy Lorraine [Youth] | 4:1 | ||||
| 4. Round | 12/09/2021 | ASPTT Dijon [Youth] | - | Olympique Lyonnais [Youth] | 0:3 | ||||
| 6. Round | 26/09/2021 | Clermont Foot 63 [Youth] | - | Olympique Lyonnais [Youth] | 1:1 | ||||
| 7. Round | 03/10/2021 | Olympique Lyonnais [Youth] | - | AJ Auxerre [Youth] | 2:1 | ||||
| 10. Round | 24/10/2021 | Olympique Lyonnais [Youth] | - | ESTAC Troyes [Youth] | 2:0 | ||||
| 15. Round | 16/01/2022 | US Torcy [Youth] | - | Olympique Lyonnais [Youth] | 0:1 | ||||
| 17. Round | 06/02/2022 | RC Strasbourg [Youth] | - | Olympique Lyonnais [Youth] | 1:1 | ||||
| 18. Round | 13/02/2022 | Olympique Lyonnais [Youth] | - | Clermont Foot 63 [Youth] | 3:3 |  |
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| 19. Round | 06/03/2022 | AJ Auxerre [Youth] | - | Olympique Lyonnais [Youth] | 1:1 | ||||
| 24. Round | 17/04/2022 | Dijon FCO [Youth] | - | Olympique Lyonnais [Youth] | 0:3 |
France