| 3. Round | 10/09/2010 | VfL Osnabrück | - | Erzgebirge Aue | 3:2 | ||||
| 4. Round | 19/09/2010 | FC Augsburg | - | VfL Osnabrück | 2:2 | ||||
| 7. Round | 02/10/2010 | VfL Osnabrück | - | Fortuna Düsseldorf | 2:3 |  |
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| 13. Round | 19/11/2010 | VfL Osnabrück | - | Hertha BSC | 2:0 | ||||
| 14. Round | 26/11/2010 | FSV Frankfurt | - | VfL Osnabrück | 4:1 | ||||
| 15. Round | 03/12/2010 | VfL Osnabrück | - | SC Paderborn 07 | 2:2 | ||||
| 17. Round | 19/12/2010 | VfL Osnabrück | - | FC Ingolstadt 04 | 2:1 |  |
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| 18. Round | 16/01/2011 | MSV Duisburg | - | VfL Osnabrück | 4:1 | ||||
| 19. Round | 21/01/2011 | VfL Osnabrück | - | TSV 1860 München | 0:1 |
Slovakia