| 1. Round | 29/07/1978 | FV Würzburg 04 | - | SpVgg Fürth | 1:1 | ||||
| 2. Round | 09/08/1978 | 1. FC Saarbrücken | - | FV Würzburg 04 | 3:1 | ||||
| 3. Round | 12/08/1978 | FV Würzburg 04 | - | SpVgg Bayreuth | 1:2 |  |
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| 4. Round | 19/08/1978 | Waldhof Mannheim | - | FV Würzburg 04 | 2:0 | ||||
| 5. Round | 26/08/1978 | FV Würzburg 04 | - | FC Augsburg | 1:3 | ||||
| 6. Round | 02/09/1978 | KSV Baunatal | - | FV Würzburg 04 | 3:1 | ||||
| 7. Round | 09/09/1978 | FV Würzburg 04 | - | Freiburger FC | 2:0 | |
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| 8. Round | 16/09/1978 | FC Hanau 93 | - | FV Würzburg 04 | 3:1 | ||||
| 9. Round | 30/09/1978 | FV Würzburg 04 | - | FSV Frankfurt | 0:2 | ||||
| 10. Round | 08/10/1978 | Borussia Neunkirchen | - | FV Würzburg 04 | 4:1 | ||||
| 11. Round | 15/10/1978 | FV Würzburg 04 | - | TSV 1860 München | 2:2 |  |
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| 12. Round | 21/10/1978 | MTV Ingolstadt | - | FV Würzburg 04 | 2:0 | ||||
| 13. Round | 28/10/1978 | Karlsruher SC | - | FV Würzburg 04 | 4:1 | |
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| 14. Round | 03/11/1978 | FV Würzburg 04 | - | Eintracht Trier | 3:1 | |
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| 15. Round | 11/11/1978 | Stuttgarter Kickers | - | FV Würzburg 04 | 2:0 | ||||
| 16. Round | 17/11/1978 | FV Würzburg 04 | - | SC Freiburg | 1:3 | ||||
| 17. Round | 24/11/1978 | Wormatia Worms | - | FV Würzburg 04 | 1:1 |
Germany