| 1. Round | 25/01/2025 | 2 de Mayo | - | Club Nacional | 0:0 | ||||
| 2. Round | 29/01/2025 | Club Nacional | - | Libertad | 0:3 | ||||
| 3. Round | 01/02/2025 | Cerro Porteño | - | Club Nacional | 3:1 |  |
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| 4. Round | 08/02/2025 | Deportivo Recoleta | - | Club Nacional | 1:0 | ||||
| 5. Round | 15/02/2025 | Club Nacional | - | Guaraní | 1:2 | |
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| 6. Round | 22/02/2025 | Sportivo Ameliano | - | Club Nacional | 2:1 | ||||
| 7. Round | 01/03/2025 | Club Nacional | - | Atlético Tembetary | 1:0 | ||||
| 8. Round | 10/03/2025 | Sportivo Luqueño | - | Club Nacional | 2:1 | ||||
| 9. Round | 17/03/2025 | Club Nacional | - | Sportivo Trinidense | 1:1 | ||||
| 10. Round | 22/03/2025 | Club Olimpia | - | Club Nacional | 0:1 | |
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| 11. Round | 30/03/2025 | Club Nacional | - | General Caballero DJLM | 1:0 | |
Paraguay