| 1. Round | 29/08/2021 | Fidelis Andria | - | SS Juve Stabia | 1:1 |  |
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| 2. Round | 04/09/2021 | Calcio Catania | - | Fidelis Andria | annull. | |
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| 3. Round | 12/09/2021 | Fidelis Andria | - | Virtus Francavilla | 0:1 | ||||
| 4. Round | 19/09/2021 | Fidelis Andria | - | Vibonese Calcio | 1:1 |  |
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| 5. Round | 26/09/2021 | Campobasso | - | Fidelis Andria | 1:3 | ||||
| 6. Round | 29/09/2021 | Fidelis Andria | - | Foggia Calcio | 0:3 | ||||
| 9. Round | 17/10/2021 | Fidelis Andria | - | US Avellino | 1:1 | ||||
| 10. Round | 20/10/2021 | Taranto FC | - | Fidelis Andria | 2:1 | ||||
| 11. Round | 24/10/2021 | Fidelis Andria | - | FC Turris | 1:0 | ||||
| 12. Round | 30/10/2021 | Latina Calcio | - | Fidelis Andria | 1:0 | ||||
| 13. Round | 07/11/2021 | Fidelis Andria | - | Palermo FC | 0:2 | ||||
| 14. Round | 14/11/2021 | Paganese Calcio | - | Fidelis Andria | 0:1 | ||||
| 15. Round | 21/11/2021 | Fidelis Andria | - | SSC Bari | 0:3 | |
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| 16. Round | 28/11/2021 | ACR Messina | - | Fidelis Andria | 2:3 | ||||
| 17. Round | 05/12/2021 | Fidelis Andria | - | AZ Picerno | 2:3 | ||||
| 19. Round | 19/12/2021 | Fidelis Andria | - | SS Monopoli 1966 | 1:2 | |
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| 20. Round | 22/12/2021 | SS Juve Stabia | - | Fidelis Andria | 1:1 |
Italy