| 7. Round | 17/10/2021 | UD San Fernando | - | CP Cacereño | 1:1 | ||||
| 10. Round | 07/11/2021 | CP Cacereño | - | CD San Roque | 1:1 | ||||
| 11. Round | 14/11/2021 | Córdoba CF | - | CP Cacereño | 5:0 | ||||
| 18. Round | 02/02/2022 | CP Cacereño | - | Vélez CF | 2:0 | ||||
| 20. Round | 06/02/2022 | CP Cacereño | - | Cádiz CF B | 1:1 | ||||
| 28. Round | 03/04/2022 | CP Cacereño | - | Córdoba CF | 2:2 | ||||
| 31. Round | 24/04/2022 | CP Cacereño | - | Mérida AD | 1:2 |  |
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| 34. Round | 15/05/2022 | AD Ceuta FC | - | CP Cacereño | 3:0 |
Spain