| 23. Round | 12/02/2016 | Bor. Mönchengladbach II | - | FC Schalke 04 II | 2:2 |  |
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| 24. Round | 20/02/2016 | Rot-Weiß Oberhausen | - | FC Schalke 04 II | 4:2 | ||||
| 26. Round | 16/03/2016 | Borussia Dortmund II | - | FC Schalke 04 II | 1:1 | ||||
| 31. Round | 28/03/2016 | FC Schalke 04 II | - | TuS Erndtebrück | 1:0 | ||||
| 33. Round | 09/04/2016 | FC Schalke 04 II | - | FC Wegberg-Beeck | 2:0 | ||||
| 34. Round | 16/04/2016 | SSVg Velbert | - | FC Schalke 04 II | 0:0 | ||||
| 25. Round | 20/04/2016 | FC Schalke 04 II | - | FC Kray | 2:0 | ||||
| 27. Round | 04/05/2016 | FC Schalke 04 II | - | SC Wiedenbrück | 1:0 | ||||
| 36. Round | 07/05/2016 | Fortuna Düsseldorf II | - | FC Schalke 04 II | 2:0 | ||||
| 37. Round | 14/05/2016 | FC Schalke 04 II | - | SC Verl | 1:2 | ||||
| 38. Round | 21/05/2016 | Viktoria Köln | - | FC Schalke 04 II | 2:1 |
Germany