| 2. Round | 21/08/2021 | SV Darmstadt 98 [Youth] | - | Eintracht Frankfurt [Youth] | 2:1 | ||||
| 3. Round | 11/09/2021 | Eintracht Frankfurt [Youth] | - | 1. FC Heidenheim 1846 [Youth] | 1:1 | ||||
| 4. Round | 18/09/2021 | Kickers Offenbach [Youth] | - | Eintracht Frankfurt [Youth] | 0:3 | ||||
| 5. Round | 25/09/2021 | Eintracht Frankfurt [Youth] | - | SC Freiburg [Youth] | 4:0 |  |
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| 6. Round | 02/10/2021 | SSV Ulm 1846 [Youth] | - | Eintracht Frankfurt [Youth] | 1:2 | ||||
| 7. Round | 16/10/2021 | Eintracht Frankfurt [Youth] | - | Bayern München [Youth] | 2:3 | |
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| 8. Round | 24/10/2021 | FC Augsburg [Youth] | - | Eintracht Frankfurt [Youth] | 3:3 | ||||
| 9. Round | 30/10/2021 | Eintracht Frankfurt [Youth] | - | 1. FC Saarbrücken [Youth] | 3:0 |
Spain